‘Sure, which is about proper. I hunt for a Bodily knowledge of biological systems in a bottom-up way. I think you could distinguish a few strains of investigation in my group in the meanwhile. The 1st worries chromosome framework: How can you obtain a metre-lengthy DNA polymer folded and organised in this kind of microscopic mobile? We now have produced visualisation strategies that enable us to study how, as an example, SMC proteins loop DNA (video on Youtube) so that you can Establish up chromosomes.

Human Rad51 filaments on double- and one-stranded DNA: correlating typical and irregular forms with recombination functionality.

Like a individual, I hold the biblical assignment to explore and use anything in creation for the good thing about my neighbour. I don't working experience any conflict among religion and science. On the contrary, my religion stimulates me to do science, being open-minded on this planet.’

Sculpting nano-electrodes that has a transmission electron beam for electrical and geometrical characterization of nanoparticles.

This yielded a breakthrough. In just a few months, we had been capable of measure transport as a result of somebody solitary-walled carbon nanotube. Determined by lower-temperature experiments by an excellent PhD pupil in my team, Sander Tans (now a valued colleague and professor at Delft College of Know-how using an active research lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes ended up real quantum wires with quite extended (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.

Instance (three) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim of your pore is highlighted in crimson, in addition to a 3D rendering on the movement in the DNA rod is exhibited.

Lots of associated developments followed, exactly where our group founded different transistor variants for instance single-electron transistors at home temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled multiple transistors into modest evidence-of-principle Digital circuits.

Nanopores stand for a chic and multipurpose Device to evaluate single molecules. We exploration novel detection modes with strong-condition nanopores in addition to several methods to evaluate proteins with nanopores. Projects encompass the next:

The rotors harness Electricity from the nanoscale water and ion stream that's produced by a static chemical or electrochemical potential gradient while in the nanopore, which are proven via a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Manage and operate autonomously in physiological conditions, suggesting methods to developing Vitality-transducing motors at nanoscale interfaces.

1). The existing–voltage curves showed sizeable modulations with gate voltage, even at place temperature, which was in step with band bending in a ~0.six eV bandgap semiconducting nanotube. These information also confirmed the conductance could be modulated by 6 orders of magnitude by altering the gate voltage. The effects of this do the job — a area-temperature transistor made from one carbon nanotube molecule — had been posted in Character in May https://www.ceesdekker.net perhaps 1998.

An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes

1999, to start with measurement of the wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence to get a new Luttinger description of interacting electrons in nanotubes

By way of example, we look at the nucleopore sophisticated, a gateway between the cell nucleus plus the cytoplasm. This is a very challenging procedure and so tricky to research in the mobile, so we use biomimetics. We reconstruct holes after which insert particular person elements on the nucleopore elaborate to study transport by it at The one-molecule level.’

‘I'm driven by surprise and concerns. On a material amount I obtain responses in physics, but I knowledge my deepest pleasure with God. That faith also drives my science and how I deal with people today.